In recent years, especially among children, the number of allergic diseases has been increasing, having reached 20 % of the world's population. Among these pathologies allergic rhinitis remain prevalent in children. Currently, little is known about regional features of sensitization in children in Ukraine.

The objective is to study the sensitization profile in children with perennial and seasonal allergic rhinitis in Kyiv and Kyiv region.

Sixty nine patients with an established diagnosis perennial and seasonal allergic rhinitis ages 5-17 were screened for multiplex test.

Sensitization to only one group of allergens was significantly more common in children with seasonal allergic rhinitis (41,38 %) than in children with perennial allergic rhinitis (7,5 %) (р=0,0008). The most frequent sensitization was in children with perennial allergic rhinitis to Uteroglobin (to cat Fel d 1 (70,0 %)), to saprophytic mold (to Alt a 1 (55,0 %)), to Lipocalin (to dog Can f 1 (32,5 %)), to NPC2 Family (to house dust mites Der f 2 (27,5 %) and to Der p 2 (27,5 %)), but there were never observed in children with seasonal allergic rhinitis (р=0,00). According to the results of this study, high sensitization were determined to Pectate Lyase (to Amb a 1 (50 %)) and to Beta-Expansins (to Phl p 1 (40,0 %), to Lol p 1 (37,5 %)) in children with perennial allergic rhinitis as well as the most frequent sensitization to these allergens in children with seasonal allergic rhinitis (41,38 %, 41,38 %, 41,38 % respectively). Children with perennial allergic rhinitis are significantly more sensitive to the PR-10 proteins molecule of Bet v 1 (45,0 %) and Aln g 1 (30,0 %) than children with seasonal allergic rhinitis (10,34 %, 10,34 %, 10,34 % respectively) (p=0,002 and р=0,05). 

Сhildren with perennial and seasonal allergic rhinitis are polysensitized, but polysensitization prevails in children with perennial allergic rhinitis, and children with seasonal allergic rhinitis are more often monosensitized. Sensitization to Fel d 1, to Alt a 1, to Can f 1, to Der f 2, to Der p 2 were most often in children with perennial allergic rhinitis, as well as the most frequent sensitization to Amb a 1, to Phl p 1, to Lol p 1 in children with seasonal allergic rhinitis.